|
مقاله
|
Abstract
|
|
|
Title:
|
The efficacy of Intravitreal Interferon Alpha-2b for the treatment of Experimental Endotoxin-Induced Uveitis.
|
Author(s):
|
Mehrdad Afarid, MD;Hamid Lashkarizadeh, MD; Mohammad J. Ashraf, MD; Mohammad H.Nowroozzadeh, MD; Sayed Mohammad Shafiee, Ph.D.
|
Presentation Type:
|
Oral
|
Subject:
|
Posterior Segment and Uveitis
|
Others:
|
|
Presenting Author:
|
|
Name:
|
Mehrdad Afarid
|
Affiliation :(optional)
|
Shiraz University of Medical sciences,Department of Ophthalmology, Poostchi Eye Research Center.
|
E mail:
|
afaridm@sums.ac.ir
|
Phone:
|
8435738
|
Mobile:
|
09177137735
|
|
|
Purpose:
|
To study the efficacy of intravitreal interferon alpha-2b for endotoxin-induced uveitis.
|
Methods:
|
36 rabbits were randomly allocated to one of the three groups: 1) received interferon plus balanced-salt solution; 2) received lipopolysaccharide plus interferon; and 3) received lipopolysaccharide plus balanced-salt solution. Intraocular inflammation was evaluated by slit-lamp biomicroscopy (SUN grading),binocularindirect ophthalmoscopy (BIO score), and histopathology.
|
Results:
|
Group 2 showed significantly lower anterior chamber reaction compared to group 3 (median, 3 vs. 4) on day 1 post-injection,lower vitreous cells on days 1 through 7 (day 1: 3 vs. 4; days 3 and 7: 1 vs. 4), and lower BIO score on days 1-7 (days 1 and 3: 3 vs. 4.5; day 7: 2 vs. 4).The protein content of anterior and vitreous aspirates were lower in group 2 than 3 (1618.5±411.4 vs. 2567.3±330.8, and 2157.0±283.3 vs. 3204.6±259.5, respectively).
|
Conclusion:
|
Intravitreal interferon alpha-2b was effective in controlling endotoxin-induced uveitis.
|
Attachment:
|
|
|