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       XXIV Annual Congress of the Iranian Society of Ophthalmology        بـیــست و چهارمین کنــگــره سـالیـانه انـجـمـن چـشـم پـزشـکی ایـــران
مقاله Abstract


Title: The efficacy of Intravitreal Interferon Alpha-2b for the treatment of Experimental Endotoxin-Induced Uveitis.
Author(s): Mehrdad Afarid, MD;Hamid Lashkarizadeh, MD; Mohammad J. Ashraf, MD; Mohammad H.Nowroozzadeh, MD; Sayed Mohammad Shafiee, Ph.D.
Presentation Type: Oral
Subject: Posterior Segment and Uveitis
Others:
Presenting Author:
Name: Mehrdad Afarid
Affiliation :(optional) Shiraz University of Medical sciences,Department of Ophthalmology, Poostchi Eye Research Center.
E mail: afaridm@sums.ac.ir
Phone: 8435738
Mobile: 09177137735
Purpose:

To study the efficacy of intravitreal interferon alpha-2b for endotoxin-induced uveitis.

Methods:

36 rabbits were randomly allocated to one of the three groups: 1) received interferon plus balanced-salt solution; 2) received lipopolysaccharide plus interferon; and 3) received lipopolysaccharide plus balanced-salt solution. Intraocular inflammation was evaluated by slit-lamp biomicroscopy (SUN grading),binocularindirect ophthalmoscopy (BIO score), and histopathology.

Results:

Group 2 showed significantly lower anterior chamber reaction compared to group 3 (median, 3 vs. 4) on day 1 post-injection,lower vitreous cells on days 1 through 7 (day 1: 3 vs. 4; days 3 and 7: 1 vs. 4), and lower BIO score on days 1-7 (days 1 and 3: 3 vs. 4.5; day 7: 2 vs. 4).The protein content of anterior and vitreous aspirates were lower in group 2 than 3 (1618.5±411.4 vs. 2567.3±330.8, and 2157.0±283.3 vs. 3204.6±259.5, respectively).

Conclusion:

Intravitreal interferon alpha-2b was effective in controlling endotoxin-induced uveitis.

Attachment:





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  - بـیــست و چهارمین کنــگــره سـالیـانه انـجـمـن چـشـم پـزشـکی ایـــران