|
مقاله
|
Abstract
|
|
|
|
Title:
|
In Vivo Evaluation of Efficacy of Systemic Administration of Oral Slow Release Diclofenac Sodium on Intravitreal Concentration
|
|
Author(s):
|
Mostafa Naderi MD; Yunes Panahi, Pharm D, ; PhD Khosrow Jadidi MD; Mojtaba Abrishami, MD; Mahmoud Babayi MD; Zohreh Pour-Saleh MD; ShahramParvin BSc
|
|
Presentation Type:
|
Oral
|
|
Subject:
|
Posterior Segment and Uveitis
|
|
Others:
|
|
|
Presenting Author:
|
|
|
Name:
|
Mojtaba Abrishami
|
|
Affiliation :(optional)
|
Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran ; Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
|
|
E mail:
|
mojtaba_abrishami@yahoo.com
|
|
Phone:
|
02166481649
|
|
Mobile:
|
09155207987
|
|
|
|
|
Purpose:
|
To assess the efficacy of slow release 100 mg oral diclofenac sodium in penetrating and preparing intravitreal concentration in experimental model and comparing chemical injured and virgin eyes.
|
|
Methods:
|
In this experimental double-masked clinical trial,24albino rabbits were included in the study. Right eyes of all rabbits were chemically injured by 1 N NaOH. One hour after chemical injury, 10 cc suspension gavage containing 100 mg slow release diclofenac sodium was administered in all cases. 2, 4, 6, 12, 24, 48 hours after gavage, vitreous samples were obtained in all cases. Intravitreal concentration of diclofenac sodium was evaluated in all samples using HPLC method.
|
|
Results:
|
In this study, we found that intravitreal diclofenac sodium levels by oral intake were enhanced by the inflammation significantly. After 6 hours, diclofenac concentration was not significant in the vitreous and reduced below 1?g/ml.
|
|
Conclusion:
|
Diclofenac is delivered to the inflamed eye more than healthy eye. It seems that by oral diclofenac, it is possible to make a significant intravitreal concentration. This study proposes an alternative intravitreal drug delivery system for intraocular inflammation control.
|
|
Attachment:
|
|
|