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مقاله
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Abstract
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Title:
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Penetration of silicate nanoparticles to the corneal stroma and intraocular fluids
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Author(s):
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Mehrdad Mohammadpour MD 1, 2, Hassan Hashemi MD3, 1-, Mahmoud Jabbarvand MD 1 , Elham Delrish2* MSc
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Presentation Type:
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Oral
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Subject:
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Cornea and Anterior Segment
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Others:
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Presenting Author:
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Name:
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Mehrdad Mohammadpour
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Affiliation :(optional)
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1- Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences. 2- Nano-Ophthalmology Department, Stem Cells Preparation Unit, Eye Research Center, Farabi Eye Hospital, Tehran Un
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E mail:
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mahammadpour@yahoo.com
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Phone:
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55421006
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Mobile:
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09123497791
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Purpose:
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To investigate transmission of topical silicate nanoparticles (SiNPs) through the corneal stroma, anterior chamber and vitreous fluids by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and inductively coupled plasma atomic emission spectrometry (ICP-AES), respectively.
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Methods:
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SiNPs with mean diameter of 40.6±5.6 nm determined by dynamic light scattering (DLS) were used in this study. The permeability of SiNPs was examined across isolated corneal buttons over a 30-minute period.
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Results:
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The determined range of synthesized SiNPs by DLS was 40 nm (41.9±5.6nm). Transmission of SiNPs through the corneal stroma was shown successfully with electron microscopy (SEM and TEM) images. The ICP results revealed SiNPs in anterior chamber and vitreous fluid.
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Conclusion:
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Topical administration of SiNPs, as a non-invasive, and available modality with acceptable penetration through the corneal stroma and deep to the intraocular fluids including anterior chamber and vitreous cavity, may be considered as a suitable alternative to invasive intravitreal injection of other expensive anti-neovascularization agents.
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Attachment:
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