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مقاله
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Abstract
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Title:
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Prophylactic effect of Topical Silica Nanoparticles as a novel anti neovascularization agent for inhibiting Corneal Neovascularization following Chemical Burn
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Author(s):
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Mehrdad Mohammadpour MD 1, 2, Mahmoud Jabbarvand MD 1, Hassan Hashemi MD3, 1, Elham Delrish2* MSc
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Presentation Type:
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Oral
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Subject:
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Cornea and Anterior Segment
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Others:
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Presenting Author:
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Name:
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Mehrdad Mohammadpour
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Affiliation :(optional)
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Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences. 2- Nano-Ophthalmology Department, Stem Cells Preparation Unit, Eye Research Center, Farabi Eye Hospital, Tehran Universi
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E mail:
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mahammadpour@yahoo.com
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Phone:
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55421006
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Mobile:
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09123497791
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Purpose:
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The purpose of this study was to investigate the anti neovascularization effect of topical silica nanoparticles in inhibiting chemical burn induced corneal neovascularization.
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Methods:
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A total number of 20 corneas of 10 Wistar Albino rats were included in this study. Silver nitrate cauterization was pressed to the central cornea for 5 seconds to induce corneal neovascularization. They were randomly allocated to case and control groups (10 eyes in each group). Silica nanoparticles (SiNPs) were synthesized by the reverse microemulsion method. SiNPs drop 1mg/ml was started in 10 eyes and artificial tear drop was started in control group (10 eyes) immediately after chemical cauterization.
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Results:
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Scanning electron microscopy (SEM) images showed spherical-shaped of particles. The mean size and polydispersity index of prepared SiNPs were 30.1±5.6 nm and 0.254±0.11, respectively. 14 days after chemical cauterization, the mean vascularized corneal area was 21% of total corneal area in case group and 85% in control group (P<0.05). The control group revealed more extensive intrastromal vascularization in compare to the case group in histopathologic examinations (P<0.05).
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Conclusion:
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SiNPs is an effective modality for inhibiting corneal neovascularization following chemical burn in experimental model. Further investigations are suggested for evaluation of its safety and efficacy in human experiments.
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Attachment:
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