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مقاله
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Abstract
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Title:
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Serum levels of interferons in patients with age related macular degeneration
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Author(s):
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Mehrdad Afarid , Ali Azimi , Mahyar Malekzadeh
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Presentation Type:
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Poster
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Subject:
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Posterior Segment and Uveitis
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Others:
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Presenting Author:
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Name:
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Mehrdad Afarid
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Affiliation :(optional)
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ophthalmology department , Poostchi ophthalmology research center,institute of cancer research,shiraz university of medical sciences
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E mail:
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afaridm@sums.ac.ir
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Phone:
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Mobile:
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09177137735
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Purpose:
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The aim of this study is evaluation of the serum level of interferons in patients with AMD .
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Methods:
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Forty two patients with AMD (dry and wet), and 42 age and sex match controls were selected. We excluded participants with history of other systemic problems, autoimmune disorders ,history of infection , surgery ,history of usage of immunosuppressive or immunogenic drugs in previous one month ago. Blood samples were received from all participants and send for measurement of serum levels of interferons ( alpha, betha and gama) .Serum levels were compare between groups with statistical analysis.
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Results:
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The level of interferon alpha in all individuals except in one patient was bellow the sensitivity of alpha interferon kit. Mean level of betha and gama interferons in patient and control groups were 34.89(SD=18.8) ,46.88(SD=27.25) (P=0.02) and 2.45(SD=9.6) , 2.66 (SD=15.04) (p=0.93) respectively .
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Conclusion:
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Level of the serum betha interferon was different in patients with AMD and it may have diagnostic, therapeutic or prognostic values that should be cleared in the future studies.
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Attachment:
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5968.pptx
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