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مقاله
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Abstract
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Title:
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Role of Fasudil in the Management of Persistent Corneal Graft Edema
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Author(s):
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Alireza Baradaran-Rafii, MD; Hamidreza Hasani, MD
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Presentation Type:
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Poster
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Subject:
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Cornea and Anterior Segment
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Others:
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Presenting Author:
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Name:
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Hamidreza Hasani
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Affiliation :(optional)
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Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences
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E mail:
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hamidrezahasani@yahoo.com
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Phone:
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02122772819
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Mobile:
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09121759054
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Purpose:
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Purpose:To report cases of corneal
persistent graft edema that was
successfully treated by Rhoassociated
kinase (ROCK)
inhibitors.
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Methods:
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Methods:3 eyes unresponsive to medical
treatment(BCVA ≤4/100)underwent
sub-conjunctival Fasudil injection
(0.5 mg/1 ml) 2 times with two
weeks interval time.
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Results:
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Results:Corneal clarity recovered and vision
improved 4-6 weeks after the second injection. At three months,
vision improved to 20/160. Average
central corneal thickness was
579+/-10 ?m, significantly lower
than its pretreatment value (744+/-9
?m).The average corneal endothelial density in the central cornea increased from 894 ± 64 to
1549.3 ± 98 cells/mm³.
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Conclusion:
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conclusion:These cases highlight
the possibility of the use of
subconjunctival ROCK inhibitors as
an alternative to regraft surgery for
certain forms of persistent corneal
graft edema.
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Attachment:
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7008.pptx
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