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       XXIV Annual Congress of the Iranian Society of Ophthalmology        بـیــست و چهارمین کنــگــره سـالیـانه انـجـمـن چـشـم پـزشـکی ایـــران
مقاله Abstract


Title: Role of Fasudil in the Management of Persistent Corneal Graft Edema
Author(s): Alireza Baradaran-Rafii, MD; Hamidreza Hasani, MD
Presentation Type: Poster
Subject: Cornea and Anterior Segment
Others:
Presenting Author:
Name: Hamidreza Hasani
Affiliation :(optional) Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences
E mail: hamidrezahasani@yahoo.com
Phone: 02122772819
Mobile: 09121759054
Purpose:

Purpose:To report cases of corneal persistent graft edema that was successfully treated by Rhoassociated kinase (ROCK) inhibitors.

Methods:

Methods:3 eyes unresponsive to medical treatment(BCVA ≤4/100)underwent sub-conjunctival Fasudil injection (0.5 mg/1 ml) 2 times with two weeks interval time.

Results:

Results:Corneal clarity recovered and vision improved 4-6 weeks after the second injection. At three months, vision improved to 20/160. Average central corneal thickness was 579+/-10 ?m, significantly lower than its pretreatment value (744+/-9 ?m).The average corneal endothelial density in the central cornea increased from 894 ± 64 to 1549.3 ± 98 cells/mm³.

Conclusion:

conclusion:These cases highlight the possibility of the use of subconjunctival ROCK inhibitors as an alternative to regraft surgery for certain forms of persistent corneal graft edema.

Attachment: 7008.pptx





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  - بـیــست و چهارمین کنــگــره سـالیـانه انـجـمـن چـشـم پـزشـکی ایـــران