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       XXIV Annual Congress of the Iranian Society of Ophthalmology        بـیــست و چهارمین کنــگــره سـالیـانه انـجـمـن چـشـم پـزشـکی ایـــران
مقاله Abstract


Title: The effect of nanoformulation of ciprofloxacin in pseudomonas keratitis
Author(s): Davaran S,Alizaeh ghavidel L,Lotfipoor F,Javadzadeh Y,Salehi R,Sedghipour MR
Presentation Type: Oral
Subject: Cornea and Anterior Segment
Others:
Presenting Author:
Name: Mohammad reza Sedghipoor
Affiliation :(optional) Tabriz University of Medical Sciences
E mail: sedghipm@yahoo.com
Phone: 041-33306619
Mobile: 09141159811
Purpose:

To compare the effect of nano formulation with marketed solution of ciprofloxacin for the treatment of pseudomona keratitis.

Methods:

Crosslinked poly (NIPAAm-MAA-VP) copolymer was used for preparation of ciprofloxacin-loaded nanoparticles. P. aeroginosa (ATCC: 9027) was used in 10 rabbit eyes(2 control,8 trial) under GA using ketamine and zylazin. In group A, nanodrug 1mg/ml and in group B 3mg/mL was used on the left eye. The positive control (right eyes) in both groups received aqueous solution of ciprofloxacin 0.03% made in laboratory.

Results:

The keratitis in starting control rabbits developed total wound extension over the study period. reduction of ulcer area from day 7 to 14 was compared for three trial modalities. the efficacy of nanoformulation in its two concentrations didn’t differ in mild or moderate keratitis , whereas in severe cases, the high concentrated drug was more effective than conventional.

Conclusion:

Nanoformulation of ciprofloxacin is suitable for sustained topical drug delivery and a viable alternative to conventional eye drops for the treatment of pseudomona keratitis .

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  - بـیــست و چهارمین کنــگــره سـالیـانه انـجـمـن چـشـم پـزشـکی ایـــران