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مقاله
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Abstract
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Title:
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Tear film inflammatory mediators in keratoconus
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Author(s):
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rana sorkhabi, amir ghorbani,nazli taheri, mohamadhosein ahoor
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Presentation Type:
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Oral
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Subject:
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Cornea and Anterior Segment
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Others:
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Presenting Author:
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Name:
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Rana Daei sorkhabi
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Affiliation :(optional)
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Tabriz university of medical sciences
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E mail:
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sorkhabi_r@yahoo.com
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Phone:
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4770545
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Mobile:
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09143153771
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Purpose:
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To determine the concentration of inflammatory mediators in the tear film from patients with keratoconus.BAsal tears from patients were collected using a capillary tube.
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Methods:
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Seventy-two subjects were enrolled in the study including 42 patients with keratoconus and 30 normals.The concentration of cytokines including Interleukin 6,10,1b and Interferon-gamma was measured by ELISA.
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Results:
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Patients with keratoconus had significantly higher levels of Interlukin-6,1b and Interferon-? compared with control subjects. But the level of Interlukin-10 in keratoconus patients was significantly lower than controls.
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Conclusion:
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This study showed that in tear film of keratoconus patients the proinflammatory markers (Interlukin-6,1-b and Interferon-γ) are over expressed, whereas the anti- inflammatory marker (Interlukin-10) is under expressed, indicating that the pathogenesis of keratoconus may involve complex chronic inflammatory events.w
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Attachment:
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