|
مقاله
|
Abstract
|
|
|
|
Title:
|
Investigating the CFH gene polymorphisms as a risk factor for age related macular degeneration in Iranian population
|
|
Author(s):
|
Mojgan Babanejad, Hamidreza Moein, Mohammad R. Akbari, Azadeh Badiei, Mehdi Yaseri, Hossein Najmabadi, Masoud Soheilian
|
|
Presentation Type:
|
Oral
|
|
Subject:
|
Posterior Segment and Uveitis
|
|
Others:
|
|
|
Presenting Author:
|
|
|
Name:
|
Masoud Soheilian
|
|
Affiliation :(optional)
|
Ophthalmic Research Center and Ophthalmology Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
|
|
E mail:
|
masoud_soheilian@yahoo.com
|
|
Phone:
|
|
|
Mobile:
|
09121755936
|
|
|
|
|
Purpose:
|
T conduct a case-control study to investigate the association 4 SNP (dbSNP ID: rs800292, rs1061170, rs2274700 and rs3753395) of CFH gene with AMD in the Iranian population.
|
|
Methods:
|
We recruited 100 AMD patients and 100 age and sex matched normal controls. Direct sequencing for 3 SNPs (rs800292, rs2274700 and rs3753395) and restriction fragment length polymorphism utilized for rs1061170. Allele and genotype frequencies of SNPs were calculated and tested for departure from Hardy–Weinberg equilibrium using the Chi-square. An allelic and genotypic association was compared by logistic regression analysis using the SNPassoc.
|
|
Results:
|
According to our results, the frequencies of risk allele for all SNPs (G, G, A and C alleles of rs800292, rs2274700, rs3753395 and rs1061170, respectively) were significantly higher in AMD patients (p<0.001). AMD individuals who had at least one copy of the C allele of rs1061170 had an increased risk of disease compared with cases with the T allele. Other studied polymorphisms showed the same association.
|
|
Conclusion:
|
Our results suggest the contribution of the all four predicted CFH polymorphisms in AMD susceptibility among the Iranian population. This association with CFH may lead to early detection and new strategies for prevention and treatment of AMD.
|
|
Attachment:
|
|
|