|
مقاله
|
Abstract
|
|
|
|
Title:
|
The Effect of Periocular Injection of Celecoxib and Propranolol on Ocular Level of Vascular Endothelial Growth Factor in a Diabetic Mouse Model
|
|
Author(s):
|
Mostafa Feghhi, MD Alireza Kheirollah, Ph.D; Gholamreza Houshmand, PhD; Nariman Nassiri, MD MPH; Saman Nassiri, MD;
|
|
Presentation Type:
|
Oral
|
|
Subject:
|
Posterior Segment and Uveitis
|
|
Others:
|
|
|
Presenting Author:
|
|
|
Name:
|
Mostafa Feghhi
|
|
Affiliation :(optional)
|
5Department of Ophthalmology, Imam Khomeini Medical Center, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
|
|
E mail:
|
feghhim671@live.com
|
|
Phone:
|
09161183228
|
|
Mobile:
|
09161183228
|
|
|
|
|
Purpose:
|
To investigate the effects of periocular injection of Propranolol and Celecoxib on ocular levels of vascular endothelial growth factor (VEGF) in a diabetic mouse model.
|
|
Methods:
|
In this experimental study, forty 4-6 week BALB-C male mice weighing 20-25 gram were used. The study groups included: non-diabetic control (group 1), diabetic control (group 2), diabetic Propranolol (group 3), and diabetic Celecoxib (group 4). After induction of type 1 diabetes by Streptozotocin, Propranolol (10μgr) and Celecoxib (200μgr dissolved in CMC 0.5%) were injected periocularly. The ocular level of VEGF was measured in all the study groups using ELISA method.
|
|
Results:
|
The VEGF level was increased (1.25 fold) in ocular tissues of the non-diabetic control group one week after induction of diabetes (P=0.002). Both periocular Propranolol and Celecoxib significantly reduced ocular VEGF levels (P=0.047 and P<0.001, respectively). The effect was more pronounced with Celecoxib
|
|
Conclusion:
|
The periocular administration of Propranolol and Celecoxib can significantly reduce ocular VEGF levels in diabetic mouse model.
|
|
Attachment:
|
|
|