to evaluate the biometric changes measured by anterior segment optical coherence tomography (AS-OCT) in acute angle closure glaucoma (AACG) with laser peripheral iridotomy (LPI)

In this prospective interventional study, 40 eyes of 40 patients with broken AACG attack were included. They underwent AS-OCT imaging before LPI and six weeks later. Angle opening distance at 750μm from scleral spur, anterior chamber angle, anterior chamber depth (ACD) and lens vault (LV) were measured. The eyes with LV/(LV+ACD)>1/3 were considered to have exaggerated LV. The main outcome measure was the change in mean of the nasal and temporal angle opening distance at 750μm from scleral spur (diff-AOD-750).

There was a significant change in ACD, nasal and temporal angle opening distance at 750?m from scleral spur and anterior chamber angle, and their mean (AOD-750 and ACA respectively) (p-value range from <0.001 to 0.007) in all eyes and the exaggerated LV subgroup. None of these parameters changed significantly in non-exaggerated LV eyes. Diff-AOD-750 was significantly correlated with pre-LPI AOD-750 (regression coefficient=-0.685, p=0.01).

LPI significantly changes the angle parameters in AACG with exaggerated LV, but the absolute change is not different in eyes with or without exaggerated LV. The less pre-LPI AOD-750 is, the more it increases with LPI.