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Title:
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Amniotic Membrane Transplantation in the Management of Acute Severe Ocular Chemical Burns
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Author(s):
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Alireza Baradaran-Rafii, MD; Hamidreza Hasani, MD
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Presentation Type:
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Oral
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Subject:
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Cornea and Anterior Segment
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Others:
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Presenting Author:
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Name:
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Hamidreza Hasani
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Affiliation :(optional)
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Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences
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E mail:
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hamidrezahasani@yahoo.com
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Phone:
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02188438227
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Mobile:
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09121759054
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Purpose:
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To evaluate the effect of amniotic membrane transplantation in the management of acute moderate and severe ocular chemical burns.
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Methods:
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Sixty eyes of 60 patients (56 male and 4 female) with acute moderate or severe chemical (acid or alkali) burns randomly received conventional medical (30 eyes) versus combined medical and surgical (30 eyes) therapies. Amniotic membrane patch sutured to entire ocular surface, within 7 days of injury in AMT group.
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Results:
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Corneal epithelial defect healed within 75.8± 29.8 days (46-170 days) in the AMT group versus 72.6 ± 30.4 (21-180 days) in medical group (p=0.610). Mean final visual acuity was 0.024± 0.655 logMAR versus -0.072± 0.5 logMAR in the AMT and medical groups, respectively (p=0.655). There was no difference in corneal neovascularization between two groups (73.3% vs 53.3%, p=0.108). Perilimbal ischemia improved in 76.41±42.8 days in the AMT group versus 89.16±44.6 days in the medical group (p=0.482). In AMT group, symblepharon developed in 6 eyes versus 10 eyes in the medical group.
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Conclusion:
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Compared to conventional medical therapy, combined amniotic membrane transplantation and medical therapy does not accelerate corneal epithelization or decrease corneal vascularization. It also does not improve perilimbal ischemia or final visual acuity.
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Attachment:
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