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Title:
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Intralesional Injection of Interferon Alpha-2b; A Novel Treatment in Orbital Eosinophilic Granuloma
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Author(s):
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Mohsen Bahmani Kashkouli, Sahab Shahrzad
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Presentation Type:
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Oral
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Subject:
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Ophthalmic Plastic and Reconstructive Surgery
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Others:
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Presenting Author:
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Name:
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Mohsen Bahmani Kashkouli
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Affiliation :(optional)
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OPRS unit, Rassoul Akram Hospital, Iran University of Medical Sciences
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E mail:
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bahmanik@yahoo.com
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Phone:
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88090456
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Mobile:
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09121777003
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Purpose:
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Considering the immune system dysfunction in unifocal orbital eosinophilic granuloma (EG); possible complications of surgery, intralesional steroid, and radiotherapy; immunomodulatory and cytoreductive effects of interferon Alpha 2b (IFN-α2b); and its safety profile in treatment of ocular surface neoplasia, intralesional IFN-α2b was firstly commenced in treatment of EG.
Aim is to report the results;Clinico-radiological-pathological; and methods of treatment.
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Methods:
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A report of a series of 3 consecutive patients (8, 25, and 43 years old males) with EG rom 2007 to 2014 who were treated with intralesional IFN-α2b after confirmation of diagnosis on histological examination.
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Results:
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Cases 1 and 3 showed a rapid response with no recurrence in 86 and 29 months follow up. Case 2, however, required a second course of injection 2 months after the first one due to a partial response to the first injections with no recurrence at last follow up (57 months). Transient flulike symptom was observed after the injections in case 2 and 3.
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Conclusion:
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This is the first report on the efficacy and safety of intralesional IFN-α2b injection in patients with EG. Long term follow up showed no side effects and recurrence.
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Attachment:
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