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مقاله
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Abstract
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Title:
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The Effect of the Fasudil, a Rho-Associated Protein Kinase Inhibitor, on Intraocular Pressure
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Author(s):
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Mohammad Pakravan, MD; Afsaneh Naderi Beni, MD; Elham Ghahari, MD; Reyhaneh Varshochian, MD; Shahin Yazdani, MD; Hamid Ahmadieh,MD
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Presentation Type:
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Oral
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Subject:
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Glaucoma
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Others:
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Presenting Author:
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Name:
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Mohammad Pakravan
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Affiliation :(optional)
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Ophthalmic Research Center, Ophthalmology Department, Labbafinejad Medical Center, Shahid Beheshti university of medical sciences
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E mail:
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mopakravan@yahoo.com
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Phone:
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22560032
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Mobile:
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09121433478
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Purpose:
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To investigate the effects of topical administration of a selective Rho-associated kinase (ROCK) inhibitor, Fasudil 0.5% and 1.2% in glaucomatous patients.
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Methods:
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In this interventional case series 4 eyes of 4 patients with unilateral end-stage primary open angle glaucoma (POAG) and no light perception vision were assigned to receive topical fasudil 0.5 and 1.2% ophthalmic solution. Dosing was twice daily for 8 weeks. At weeks 1, 2, 3, 4 and 8, ocular examinations were performed and IOP was measured. Ocular symptoms and adverse events were evaluated.
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Results:
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The mean baseline IOP was 52 mm Hg. The mean IOP reductions of the last visit from baseline were -7.75 mm Hg at 2 hours, and -8.75mmHg at 4 hours. All 2 concentrations of fasudil produced statistically and clinically significant reductions in mean IOP with peak effects occurring 2 to 4 hours after dosing. The largest IOP reductions were produced by 1.2% fasudil (up to 12 mm Hg; 21.1%). Conjunctival hyperemia was found in 1 patient with 1.2% fasudil.
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Conclusion:
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Topical administration of fasudil in patients with end–stage POAG caused a reduction in IOP and was well tolerated. ROCK inhibitors could be a candidate for glaucoma therapy in future.
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Attachment:
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