To report three cases of cherubism that one of them underwent surgery for orbital manifestations

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Our patients developed painless enlarging of the cheeks and jaws when they had been 4-5 years old. Ophthalmologic examinations showed mild proptosis, and superior globe displacements in all cases. Case 2 and 3 had lower lid skin discoloration. CT scans demonstrated bilateral multicystic lesions in the maxilla and mandible with cortical thinning in all cases. In case 3, left eye hyperglobus and anisometropic amblyopia was seen. The CT scan showed a round, well-defined and homogenous mass, involving anterior and superior wall of maxillary sinus on the left side, extending into inferior orbit. Debulking of the mass was performed at the surgery. The pathologic findings were compatible with the diagnosis of giant cell reparative granuloma. He returned 1 year after surgery with the recurrence of the mass.

To our knowledge, lower lid skin discoloration in cases 2 and 3, anisometropic amblyopia in case 3, and recurrence of the mass after debulking of giant cell reparative granuloma in case 3 were not described elsewhere in cherubism cases. All cases with cherubism must be examined by an ophthalmologist to diagnose and treat possible orbital manifestations.